NCT04553601

Molecular Imaging Visualization of Tumor Heterogeneity in Non-small Cell Lung Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: The First Affiliated Hospital of Xiamen University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

To assess the potential usefulness of radiogenomics for tumor driving genes heterogeneity in non-small cell lung cancer.

Detailed description

Patients with advanced NSCLC underwent 18F-FDG PET/CT and PET/CT-guided synchronous targeted biopsy of primary and distant metastatic tumors. The LIFEx package was used to extract PET and CT radiomic features from primary and metastatic lesions. The radiomic ROI sites of primary and distant metastatic tumors were point-to-point corresponding to the PET/ CT-guided targeted biopsy sites. Whole exon sequencing of primary and distant metastatic tumor samples obtained by PET/CT-guided targeted biopsy was used to get genomic data of primary and distant metastatic tumor. Predictive radiogenomics models were established and validation.

Conditions

• NSCLC
• PET/CT
• Biopsy
• Radiomics
• Genomics
• Whole-exome Sequencing

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-FDG PET/CT and PET/CT-guide targeted biopsy in another group of participants	Each subject receive a single intravenous injection of 18F-FDG PET/CT and PET/CT-guide targeted biopsy within the specified time

Timeline

• Start date: 2019-10-01
• Primary completion: 2022-10-01
• Completion: 2022-10-01
• First posted: 2020-09-17
• Last updated: 2020-09-17

Locations

1 site across 1 country: China