NCT04552938

LVA on Serum Profiling in Patients With Lymphedema

The Impact of Lymphaticovenous Anastomosis on Serum Profiling in Patients With Lymphedema

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The correlation between oxidative stress and increased lymphedematous limb volume lacks supporting evidence. Lymphedema patients are prone to cellulitis. This study aims to investigate the link between oxidative stress, limb volume, and cellulitis after supermicrosurgical lymphaticovenous anastomosis (LVA).

Detailed description

In this study, we focused on the changes in serum antioxidant biomarkers before and after LVA, detected by isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic analysis, enzyme-linked immunosorbent assay (ELISA), and Oxidative Stress Panel Kit. For clinical correlation, magnetic resonance (MR) volumetry was implemented for precise lymphedematous limb volume measurements. Correlations were made between changes in oxidative stress, limb volume, and cellulitis before and after LVA.

Conditions

• Lymphedema

Interventions

Type	Name	Description
OTHER	pre-LVA	Venous serum samples were collected from patients before LVA.
OTHER	post-LVA	Venous serum samples were collected from patients one-month after LVA.

Timeline

• Start date: 2018-04-11
• Primary completion: 2020-06-01
• Completion: 2020-09-11
• First posted: 2020-09-17
• Last updated: 2020-09-17

Locations

1 site across 1 country: Taiwan