NCT04549194

Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (actual)
• Sponsor: Direction Centrale du Service de Santé des Armées · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Operational conditions amplify soldier's constraints and stress factors, upsetting individual and collective adaptive landmarks. The soldier's resistance is strained by the high intensity of stressors, by the long duration of exposure and by their cumulative effect. This may lead to a state of "operational strain" that refers to chronic stress and the allostatic load imposed by operational constraint. The investigators believe that operational strain could manifest itself by a kind of accelerated aging of the organism due to the increased allostatic load without sufficient resource restoration (neurotransmitter precursors, partial and repeated sleep deprivation, etc.). This aging mechanism would be reversible after a sufficient period of resource restoration (sleep, physical activity, adapted diet, etc.).

Conditions

• Stress, Psychological

Interventions

Type	Name	Description
BIOLOGICAL	Blood collection	A blood sample will be collected before during and after the treatment.
DRUG	L-Tyrosine 500 Mg	The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route daily over 1 month.
BEHAVIORAL	Psychological questionnaires	The participants will fill in several psychological questionnaires before, during and after treatment administration: * Life Event Checklist * Moral injury * Posttraumatic Checklist * Burnout Assessment Tool * State-Trait Anger Expression Inventory-2 * Ruminative Response Scale - Reconsidered * Deployment Risk and Resilience Inventory-2 * Questionnaire about tobacco use
DEVICE	Photoplethysmography	Photoplethysmography recording will be performed before during and after the treatment.
DRUG	Placebo	The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route daily over 1 month.

Timeline

• Start date: 2020-09-09
• Primary completion: 2021-06-30
• Completion: 2021-06-30
• First posted: 2020-09-16
• Last updated: 2022-11-25

Locations

1 site across 1 country: France