NCT04548362

Biomarkers of Meats and Potatoes Intake

Biomarkers of Meats and Potatoes Intake: a Meal Study in Healthy Men and Women - the MEPO Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Professor Lars Ove Dragsted · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This cross-over meal study is a four-way intervention with 12 volunteers randomized at the same time to four meals with fried meats (beef, pork, chicken and amino-acid matched non-meat control) and to four meals with potato products (boiled, chips, fries, and a control with boiled white rice) to search for biomarkers of intake.

Detailed description

In a two-dimensional, cross-over meal study, 12 healthy volunteers consumed in a randomized sequence four test meals: chicken, pork, beef, and a control made of egg white and pea. At the same time they were independently randomized to four starchy foods to be consumed together with the meats: boiled potatoes, fried potatoes, potato crisps or boiled white rice. Fasting and postprandial urine samples were collected to cover 48 h after each meal and samples were profiled by untargeted LC-ESI-qTOF-MS metabolomics. The profiles following the meal challenges were explored by univariate and multivariate analyses and single and combined markers of intake identified chemically by MS/MS fragmentation experiments and statistically by ROC curves and error rates as well as FDR statistics.

Conditions

• Nutrition Disorders

Interventions

Type	Name	Description
OTHER	Meat arm	Randomised sequence of pork, beef, chicken meat, and an egg white/pea combination
OTHER	Starchy foods arm	Randomised sequence of boiled potato, fried potato, potato crisps, and boiled white rice

Timeline

• Start date: 2016-02-15
• Primary completion: 2016-05-30
• Completion: 2016-05-30
• First posted: 2020-09-14
• Last updated: 2021-04-28

Locations

1 site across 1 country: Denmark