Trials / Completed
CompletedNCT04545658
Prediction of Esophageal and Lung Toxicities After Radiation (Chemo) Therapy
Prediction of Esophageal and Lung Toxicities After Radiation (Chemo) Therapy for Lung Cancer Management
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 167 (actual)
- Sponsor
- University Hospital, Brest · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- —
Summary
(Chemo)-radiotherapy is the gold standard therapeutic treatment for patients with locally advanced lung cancer non accessible or ineligible for surgery. While some progress occurred regarding progression free survival and overall survival thanks to recent advances (i.e., durvalumab), prediction of pulmonary and esophageal toxicity, remains insufficiently accurate. Current dose-volume histograms (DVH) do not account for spatial dose distribution and strict application of current dose constraints does not prevent toxicity events in some of the treated patients. The goal of this work was to investigate the added predictive value of the radiomics approach applied to dose maps regarding acute and late toxicity in both lungs and the esophagus.
Conditions
Timeline
- Start date
- 2020-07-16
- Primary completion
- 2020-07-31
- Completion
- 2020-07-31
- First posted
- 2020-09-11
- Last updated
- 2020-09-11
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04545658. Inclusion in this directory is not an endorsement.