NCT04544540

One Versus Two Unit Transfusions in Oncology Patients - The OTTOP Trial: A Randomized Open-label Pragmatic Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this trial is to determine if the transfusion of one unit of red blood cells to anemic oncology patients results in comparable numbers of transfusion episodes when compared to transfusion of two units of red blood cells.

Detailed description

The aim of this trial is to determine if administration of one unit of red blood cells to anemic oncology patients is non-inferior to the administration of two units of red blood cells in terms of the number of annual transfusion episodes. If demonstrated, our findings will cut the total transfusion episode time in half and avoid exposure to an additional unit of red blood cells while freeing up scarce hospital resources.

Conditions

• Anemia
• Oncology

Interventions

Type	Name	Description
OTHER	Units of transfusion	Participants will either receive 1-unit or 2-unit red blood cell outpatient transfusions

Timeline

• Start date: 2020-11-01
• Primary completion: 2023-11-01
• Completion: 2024-12-01
• First posted: 2020-09-10
• Last updated: 2020-09-10