NCT04543006

Persistence of Neutralizing Antibodies 6 and 12 Months After a Covid-19

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known. The investigators will explore patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected. The investigators will determine whether this persistance varies according to * the severity of the Covid-19 * a treatment by steroids during the covid-19. This will help to anticipate whether a second wave of infection is possible in a non-naive population.

Detailed description

Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known. The investigators will explore adult patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected. The investigators will determine whether this persistance varies according to * the severity of the Covid-19 (3 groups: no oxyegn therapy; oxygen therapy of less than 3L/min; oxygen therapy of 3L/min or more) * a treatment by steroids during the covid-19. Immunocompromised patients will be excluded.

Conditions

• Covid19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	serology	blood sample of 10 ml twice (6 and 12 months after the Covid-19)

Timeline

• Start date: 2020-09-08
• Primary completion: 2021-09-30
• Completion: 2021-12-31
• First posted: 2020-09-09
• Last updated: 2020-09-16