Trials / Completed
CompletedNCT04539574
An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors
Validation of a Multi-Parametric Ultra-High Field MRI Protocol for Central Nervous System Malignancy
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (actual)
- Sponsor
- M.D. Anderson Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This trial investigates how well 7T MRI scan works in imaging central nervous system tumors. Diagnostic procedures, such as 7T MRI, may help find and diagnose central nervous system tumors and help measure a patient's response to earlier treatment. The goal of this trial is to learn if a new MRI system can provide better quality images than a standard MRI.
Detailed description
PRIMARY OBJECTIVE: I. To estimate the contrast-to-noise ratio (CNR) for several imaging modalities in brain malignancy as compared with normal brain parenchyma separately by type of malignancy and treatment status. SECONDARY OBJECTIVE: I. To assess the conspicuity of each imaging modality to differentiate radiation necrosis from progressive disease. EXPLORATORY OBJECTIVES: I. To assess patient experience in the 7 Tesla (7T) magnetic resonance imaging (MRI) system compared to their most recent MRI examination. II. To assess the typical significance values seen for areas of maximal brain activity associated with each functional MRI (fMRI) test. III. To assess the geometric distortion of a radiation planning sequence on a ultra-high field (UHF) system. OUTLINE: Patients undergo 7T MRI over 60 minutes.
Conditions
- Central Nervous System Neoplasm
- Glioma
- Metastatic Malignant Neoplasm in the Central Nervous System
- Metastatic Malignant Solid Neoplasm
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | 7 Tesla Magnetic Resonance Imaging | Undergo 7T MRI |
| OTHER | Questionnaire Administration | Ancillary studies |
Timeline
- Start date
- 2020-09-04
- Primary completion
- 2024-04-26
- Completion
- 2024-04-26
- First posted
- 2020-09-07
- Last updated
- 2025-01-08
- Results posted
- 2025-01-08
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT04539574. Inclusion in this directory is not an endorsement.