NCT04538820

Dexamethasone Dose for Postoperative Nausea and Vomiting Prophylaxis in Obese Patients

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital · Other Government
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.

Detailed description

compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients. compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients. 4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. This group will be classified as the control group. In obese patients (BMI\>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction. Patients will receive general anesthesia with volatile anesthetics and tramadol will be administered IV at the end of surgery. Postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.

Conditions

• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	Dexamethasone 4 mg IV-control	dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to normal weight patients.
DRUG	Dexamethasone 4 mg IV	dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients
DRUG	Dexamethasone 8 mg IV	dexamethasone 8 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients

Timeline

• Start date: 2021-03-01
• Primary completion: 2021-09-30
• Completion: 2021-09-30
• First posted: 2020-09-04
• Last updated: 2021-09-08

Locations

1 site across 1 country: Turkey (Türkiye)