NCT04538638

Mesenteric SParIng Versus Central mesenterectomY in Ileocolic Resection for Terminal Ileitis in Crohn's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 139 (actual)
• Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The aim of this multicenter randomised controlled trial is to analyse the six month endoscopic recurrence following a mesenteric sparing versus a central mesenterectomy performing an ileocolic resection for CD.

Detailed description

There is emerging evidence to suggest that Crohn's disease (CD) may be a disease of the mesentery rather than just of the bowel alone. A more extensive central mesenterectomy (up to the level of the ileocolic artery), in order to remove an increased volume of affected mesentery to prevent postoperative CD, has been suggested to lead to beneficial results. It is hypothesised that patients who undergo a central mesenterectomy during an ileocolic resection compared to a mesenteric sparing ileocolic resection will have decreased recurrence rates.

Conditions

• Crohn's Disease

Interventions

Type	Name	Description
PROCEDURE	Mesenteric sparing ileocolic resection	Mesentery left in situ
PROCEDURE	Central mesenterectomy ileocolic resection	Mesentery is taken up to the level of the ileocolic trunk

Timeline

• Start date: 2020-03-01
• Primary completion: 2023-05-01
• Completion: 2023-11-27
• First posted: 2020-09-04
• Last updated: 2023-12-26

Locations

1 site across 1 country: Netherlands