NCT04537871

Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

Cardiovascular Reserve Evaluation in Survivors of Transplantation (CREST)

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (actual)
• Sponsor: City of Hope Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.

Detailed description

PRIMARY OBJECTIVES: I. Evaluate cardiovascular reserve capacity, as measured by peak oxygen consumption (VO2peak), in hematopoietic cell transplantation (HCT) survivors. II. Define the determinants of VO2peak impairment in HCT survivors. OUTLINE: Patients undergo echocardiogram to assess cardiac function and mechanics, cardiopulmonary exercise test, pulmonary function test, musculoskeletal ultrasound, bioelectrical impedance analysis to measure total lean body mass and percent body fat), physical function tests, and collection of blood samples within 45 days from the start of conditioning therapy, and at 6 months, 1 year, and 2 years post-transplant.

Conditions

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Hematopoietic and Lymphoid Cell Neoplasm
• Hodgkin Lymphoma
• Myelodysplastic Syndrome
• Non-Hodgkin Lymphoma
• Plasma Cell Myeloma

Interventions

Type	Name	Description
PROCEDURE	Bioelectric Impedance Analysis	Undergo bioelectric impedance analysis
PROCEDURE	Biospecimen Collection	Undergo collection of blood samples
PROCEDURE	Cardiopulmonary Exercise Testing	Undergo cardiopulmonary exercise test
PROCEDURE	Echocardiography	Undergo echocardiogram
PROCEDURE	Physical Performance Testing	Undergo physical function tests
PROCEDURE	Pulmonary Function Test	Undergo pulmonary function test
OTHER	Questionnaire Administration	Ancillary studies
PROCEDURE	Ultrasound	Undergo musculoskeletal ultrasound

Timeline

• Start date: 2020-11-18
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2020-09-03
• Last updated: 2025-09-25

Locations

1 site across 1 country: United States