NCT04536233

Effects of MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries

The Safety and Effectiveness of Mesenchymal Stem Cell-derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Nasal trauma, deviated nasal septum, sinusitis, nasal polyps and other nasal benign diseases are common clinical diseases and require endoscopic sinus surgery. The proper application of the surgical procedure as well as ensuring high quality of wound healing, is also important to achieve successful results in endoscopic sinus surgery. If good quality wound healing cannot be achieved in the surgical field,synechiae and anatomic defects can occur that may require revision surgeries. Mesenchymal stem cells play an active role in the treatment of many diseases. it primarily exerts therapeutic effects through paracrine. In this study, the effect of mesenchymal stem cell-derived multipotent factors on mucosal repair after nasal surgery was evaluated.

Conditions

• MSCs Derived Pleiotropic Factors on Wound Healing in Endonasal Surgeries

Interventions

Type	Name	Description
BIOLOGICAL	MSCs Derived Pleiotropic Factors	The pleiotropic factor derived from mesenchymal stem cells was injected on the wound
OTHER	physiological saline	The physiological saline was injected on the wound

Timeline

• Start date: 2020-10-10
• Primary completion: 2021-01-31
• Completion: 2021-03-30
• First posted: 2020-09-02
• Last updated: 2020-09-29