NCT04533841

Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas

Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor In Primigravidas

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 128 (actual)
• Sponsor: Ahmed mohamed fathy ismail · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

To compare propranolol and misoprostol versus misoprostol alone for induction of labour in primigravidas

Detailed description

Candidates will be randomized into 2 groups according to a computer generated sequence. Each candidate will be assigned an opaque sealed envelope containing a paper with her group on it. Both the patient and doctor on duty will be blinded to which group the patient was assigned to. \- Study procedure: 1. Written informed consent will be obtained from all participants prior to the study. 2. Full history taking. 3. General examination. Patients will be subjected to the following: * Patients attending labour room for induction of labour will be divided into two groups. * Both groups, women are induced with Tab misoprostol 25μg applied to posterior vaginal fornix under aseptic precaution and every 6 hours for a maximum of 4 doses. * In group 1, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral Propanolol 20mg * In group 2, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral placebo in the form of sugary tablets. * After induction, women will be monitored for fetal and maternal wellbeing and progress of labour.

Conditions

• Induction of Labor Affected Fetus / Newborn

Interventions

Type	Name	Description
DRUG	Misoprostol	Pt will receive misoprostol for labor induction then after 30 minutes will receive ether propranolol or misoprostol
DRUG	Placebo	placebo
DRUG	Propranolol	Propranolol

Timeline

• Start date: 2020-02-01
• Primary completion: 2020-09-13
• Completion: 2020-09-15
• First posted: 2020-09-01
• Last updated: 2022-08-31

Locations

1 site across 1 country: Egypt