Trials / Completed
CompletedNCT04532684
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 66 (actual)
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital · Academic / Other
- Sex
- All
- Age
- 40 Years – 69 Years
- Healthy volunteers
- Not accepted
Summary
Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees. Addition of molecules targeting neuropathic pain to conventional therapy has been shown to improve treatment response in the management of osteoarthritis.The aim of our study is to evaluate the effect of duloxetine and pregabalin on pain, functional capacity, quality of life, depression, anxiety and sleep patterns in knee osteoarthritis.
Detailed description
A total of 66 patients (aged 40-69) with knee osteoarthritis were randomized into two treatment groups to receive either duloxetine 60mg/day or pregabalin 300mg/day. The patients were evaluated before and one month after treatment and three months after treatment using the visual analog scale (VAS-pain), Neuropathic Pain Diagnostic Questionnaire (DN4), Short Form-36 (SF-36) Questionnaire, Western Ontario and McMaster University Osteoarthritis İndeks (WOMAC), Beck Depression Scale (BDS), Beck Anxiety Akalası (BAS), Pittsburg Sleep Quality Index (PSQI).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Duloxetine | |
| DRUG | Pregabalin |
Timeline
- Start date
- 2016-10-01
- Primary completion
- 2020-07-15
- Completion
- 2020-12-15
- First posted
- 2020-08-31
- Last updated
- 2021-01-25
Source: ClinicalTrials.gov record NCT04532684. Inclusion in this directory is not an endorsement.