NCT04531696

UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

UPTIDER is a prospective, interventional, non-Investigational Medicinal Product (non-IMP), non-commercial, single centre post-mortem tissue donation program for metastatic breast cancer patients or patients with a germline pathogenic variant with a moderate to high lifetime risk of breast cancer and at least one malignancy at time of death. The overarching objective of UPTIDER is (i) to unravel metastatic breast cancer evolution, biology, heterogeneity and treatment resistance and (ii) to assess pathogenicity and tumour biology in hereditary cancer syndromes with a high lifetime risk of breast cancer; both through extensive post-mortem multi-level and multi-region sample analysis.

Conditions

• Breast Cancer
• Hereditary Diseases

Interventions

Type	Name	Description
PROCEDURE	Blood draw	Blood draw at inclusion
PROCEDURE	Post-mortem tissue collection	Sample collection (both liquids, tumour tissue and non-tumour tissue) during post-mortem research autopsy

Timeline

• Start date: 2020-11-30
• Primary completion: 2035-09-01
• Completion: 2035-09-01
• First posted: 2020-08-28
• Last updated: 2024-06-28

Locations

1 site across 1 country: Belgium