NCT04531644

Double Stimulation in Women With Low Prognosis in ART

Impact of Double Stimulation (DuoStim) in Women Affected by Low Prognosis to Assisted Reproductive Technologies

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Tu Du Hospital · Other Government
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The main objective of this study is to compare the cumulative ongoing pregnancy rates of two different IVF protocols in women candidate for ART characterized by low prognosis.

Detailed description

The patients will be allocated into two groups: control and study group \_ In study group, patients will be treated by DuoStim protocol: The first phase of ovarian stimulation is started on the second day or third day of period. GnRH agonist will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. Five days later after oocyte retrieval, the second stimulation will be started. All embryos will be cryopreserved. \_ In control group, patients will be treated with antagonist protocol: The cycle of ovarian stimulation is started on the second day or third day of period. hCG will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. If serum progesterone on the day of trigger ≥ 1.5 ng/ml, all embryos will be cryostored; otherwise, fresh embryos will be transferred.

Conditions

• Assisted Reproductive Techniques

Interventions

Type	Name	Description
PROCEDURE	double stimulation	the patients will be treated with two consecutive ovarian stimulations in one cycle
PROCEDURE	conventional ovarian stimulation	the patients will be treated with one conventional ovarian stimulation in one cycle

Timeline

• Start date: 2020-05-14
• Primary completion: 2024-02-28
• Completion: 2024-03-30
• First posted: 2020-08-28
• Last updated: 2023-12-06

Locations

1 site across 1 country: Vietnam