NCT04530513

ARREST - A Phase I Study of SABR for Poly-metastatic Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Stereotactic ablative radiotherapy (SABR) is a new radiation treatment that delivers high-dose, precise radiation to small areas in the body. This new technique can potentially allow radiation treatments to be focused more precisely, and be delivered more accurately than with older treatments. This improvement could help by reducing side effects overall (through radiation exposure to a smaller area of the body over a shorter time period), and by improving the chance of controlling the cancer by more precisely treating the cancer and by giving higher doses of radiation. SABR is considered a standard treatment for some lung cancers, and selected cancers that have spread to the brain. Ongoing studies are evaluating the use of SABR for treating people with up to 10 sites of cancer in the body, but its safety and value for treating patients with poly-metastatic cancer (more than 10 sites of cancer) is not yet known. The purpose of this study is to determine the safety of using SABR to treat people with poly-metastatic disease. To our knowledge, this is the first time that SABR will be tested in people who have poly-metastatic disease.

Conditions

• Metastatic Cancer

Interventions

Type	Name	Description
RADIATION	Stereotactic ablative radiotherapy - Level 1	6Gy x 2 fractions to all sites in 2 weeks
RADIATION	Stereotactic ablative radiotherapy - Level 2	6Gy x 3 fractions to all sites in 3 weeks
RADIATION	Stereotactic ablative radiotherapy - Level 3	6Gy x 4 fractions to all sites in 4 weeks
RADIATION	Stereotactic ablative radiotherapy - Level 4	6Gy x 5 fractions to all sites in 5 weeks
RADIATION	Stereotactic ablative radiotherapy - De-escalation Level	6Gy x 1 fraction to all sites in 1 week

Timeline

• Start date: 2020-11-17
• Primary completion: 2023-06-26
• Completion: 2025-06-15
• First posted: 2020-08-28
• Last updated: 2025-09-12

Locations

1 site across 1 country: Canada