NCT04530409

Timing of Corticosteroids in COVID-19, II. Post COVID-19 Follow-up

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 752 (actual)
• Sponsor: ClinAmygate · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Timing of of corticosteroids administration is very important in COVID19 cases for the recovery and decrease the mortality.

Detailed description

The sickest patients with COVID-19 suffer a hyperinflammatory state-a cytokine storm-that has features in common with a rare haematological condition called haemophagocytic lymphohistiocytosis. Immune suppression should help such patients. By contrast, immune suppression during the early phase of the viral infection might allow increased viral replication and aggravate the disease. The 3C-like proteinase on SARS-CoV-2 (nsp5) inhibits HDAC2 transport into the nucleus, and so impairs the way in which it mediates inflammation and cytokine responses, so activation of histone deacetylase by dexamethasone may directly oppose the action of SARS-CoV-2. Timing of of corticosteroids administration is very important in COVID19 cases for the recovery and decrease the mortality.

Conditions

• Covid19
• Corticosteroids

Interventions

Type	Name	Description
DRUG	Early-Corticosteroids	early use of dexamethasone/Methylprednisolone as early as laboratory evidence of high inflammatory markers

Timeline

• Start date: 2021-03-20
• Primary completion: 2021-11-01
• Completion: 2023-10-15
• First posted: 2020-08-28
• Last updated: 2023-09-06

Locations

1 site across 1 country: Egypt