NCT04526054

Morphological Abnormalities of the Olfactory Bulb on MRI and Olfactometry in Anosmic Versus Normosmic COVID-19 Patients

Longitudinal and Comparative Study of Morphological Abnormalities of the Olfactory Bulb on MRI and Olfactometry in Anosmic Versus Normosmic COVID-19 Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients. This study aimed to detect these disturbances among positive COVID-19 patients (symptom not initially highlighted by the patient and not sought by caregivers) in order to allow early management of olfactory and gustatory dysfunction.

Detailed description

Several medical teams have recently shown that disturbances of smell and taste are common and can be a precursor and even an isolated sign of COVID-19 involvement. Preliminary results suggest the presence of clinical MRI abnormalities, particularly in the olfactory bulbs in anosmic patients with COVID-19. Anosmia and taste disturbance are early warning signs that could be important in improving the detection and diagnosis of COVID-19, and also in monitoring disease. In addition, disturbances in smell and taste could be an aid in establishing the prognosis of the clinical course of the viral disease. The question of olfactory recovery is also fundamental. To date, we do not know the possibilities of recovery from COVID-19 post viral anosmia. ENT exams, olfactometry and MRI are proposed to study these phenomena.

Conditions

• Olfaction Disorders
• COVID-19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ENT exam	ENT examination of the nasal cavity: nasofibroscopy and anterior rhinoscopy.
DIAGNOSTIC_TEST	Olfactometry	Olfactometry test using odorous pens (Sniffin's stick test).
DIAGNOSTIC_TEST	Brain MRI	Brain MRI focused on the olfactory bulbs (3 teslas).

Timeline

• Start date: 2020-09-03
• Primary completion: 2021-09-03
• Completion: 2021-09-03
• First posted: 2020-08-25
• Last updated: 2022-08-03

Locations

2 sites across 1 country: France