NCT04525534

Plasma Concentration of Biological Markers in Placenta Accreta Spectrum

Plasma Concentration of Biological Markers in Placenta Spectrum

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 19 (actual)
• Sponsor: University of Arkansas · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this exploratory study is to determine how well maternal serum biomarkers and placental micro-particles (MP) correlate with placenta accreta spectrum (PAS) at the time of cesarean delivery in women with suspected PAS compared to women without PAS. Our aim is to determine if women with PAS have a unique MP and protein signature at the time of delivery compared with women without PAS.

Detailed description

Maternal blood samples will be taken at various points during the intrapartum period. A healthy group of women admitted for delivery will act as a matched control and will have their blood sampled at similar time points. The primary outcome variables will include the total number of micro-particles, the number of micro-particles from each cell line (platelet, placental, endothelial etc.), and protein markers The knowledge gained from this study has the potential to develop a diagnostic test for PAS with the ability to improve management and outcomes for mother and baby through earlier diagnosis.

Conditions

• Placenta Accreta
• Placenta Diseases

Interventions

Type	Name	Description
OTHER	There is no other intervention, only clinical treatment.	There is no other intervention, only clinical treatment

Timeline

• Start date: 2020-08-30
• Primary completion: 2023-07-10
• Completion: 2023-07-10
• First posted: 2020-08-25
• Last updated: 2024-09-03

Locations

1 site across 1 country: United States