NCT04525404

MOIST Study: Multi-Organ Imaging With Serial Testing in COVID-19 Infected Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 215 (actual)
• Sponsor: University of Alberta · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

While many people with COVID-19 suffer from respiratory disease, there is growing evidence that the virus also affects other organs. The purpose of this study is to better understand the effects of COVID-19 on the lungs and other organs. The study investigators have developed new techniques in Magnetic Resonance Imaging (MRI) to scan the lungs, heart, brain and liver. The study investigators hope to learn more about how the virus causes inflammation in these organs and how this inflammation changes over time as people recover from COVID-19 illness. The study aims to enroll 228 people in Alberta. Participants will undergo one or more MRI scans and have blood testing at one or more time points to assess for inflammation, kidney function, liver function and possible heart injury. Participants will also undergo testing to assess sense of smell, cognition (thinking and memory), spirometry (breathing test for lung function) and and exercise tolerance (walk test). The study investigators hope this study will help us learn more about the long-term risks of COVID-19 disease.

Detailed description

Participants with newly or recently diagnosed COVID-19 infection (inpatients and outpatients) will undergo multi-organ MRI (heart, brain, lungs, liver), blood work, and functional testing at one or more time points. Functional testing will include olfaction testing, cognitive testing, spiromety, and a walk test.

Conditions

• Covid19
• Coronavirus Infection
• SARS-CoV Infection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI (heart, brain, lungs, liver)	MRI (heart, brain, lungs, liver)
DIAGNOSTIC_TEST	Bloodwork	Serum biomarkers to assess systemic inflammation, renal function, cardiac injury, liver injury and steatosis, ACE-2 related peptides, cytokines, Activin A and autoantibodies to cardiac antigens, humoral cell RNA
OTHER	Cognitive testing	NIH toolbox Cognitive Measures
OTHER	Olfaction testing	Brief Smell Identification Test (BSIT)
DIAGNOSTIC_TEST	Spirometry	Spirometry to evaluate forced expiratory volume in 1 second and forced vital capacity
OTHER	Walk Test	Walk test to record overall distance walked in 6 minutes and time taken to walk the first 25 feet

Timeline

• Start date: 2020-11-12
• Primary completion: 2021-09-22
• Completion: 2022-09-30
• First posted: 2020-08-25
• Last updated: 2023-01-26

Locations

2 sites across 1 country: Canada