NCT04524494

Human Intestinal Amino Acid Absorption and the Role of a Local RAS

Human Intestinal Amino Acid Absorption and the Role of a Local (Renin)-Angiotensin System (RAS)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: University Children's Hospital Basel · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study is to find out what role a local intestinal RAS (renin angiotensin system) plays in the context of amino acid absorption in the human intestinal tract and how this RAS and thus the amino acid absorption is influenced by the RAS-active drugs (angiotensin II AT1 receptor blockers (sartans) or ACE inhibitors).

Conditions

• Renin-Angiotensin Aldosterone System (RAS)

Interventions

Type	Name	Description
OTHER	biopsy of intestinal tissue	4 intestinal tissue biopsies taken from descending Duodenum, 2 intestinal tissue biopsies taken from Ileum, 2 intestinal tissue biopsies taken from ascending colon (additional to routine biopsies taken for gastrointestinal diagnostic)
OTHER	blood draw	40 ml blood draw (in Heparin blood tubes) (additional to routine blood draw taken for gastrointestinal diagnostic)
OTHER	urine collection	Midstream Urine collection

Timeline

• Start date: 2010-01-27
• Primary completion: 2011-05-31
• Completion: 2011-05-31
• First posted: 2020-08-24
• Last updated: 2020-08-24

Locations

2 sites across 1 country: Switzerland