NCT04522193

Dumping Syndrome and Esophageal Atresia

Physiopathology of Dumping Syndrome in Esophageal Atresia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 2 Months – 3 Months
• Healthy volunteers: Not accepted

Summary

Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months

Conditions

• Oesophageal Atresia
• Dumping Syndrome

Interventions

Type	Name	Description
DEVICE	Glycemic Holter	Continuous glycaemia monitoring,
RADIATION	gastric emptying scintigraphy	Fasting administration of a Technecium-labelled milk bottle and quantification of the remaining radioactivity by a camera every 30 minutes for 4 hours.
DEVICE	Holter ECG	continuous cardiac monitoring

Timeline

• Start date: 2024-02-23
• Primary completion: 2026-11-01
• Completion: 2026-11-01
• First posted: 2020-08-21
• Last updated: 2025-12-23

Locations

2 sites across 1 country: France