NCT04520503

Relationship Between Pre-induction Electroencephalogram Pattern of Adult Patients and Their Sensitivity to Propofol

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

The induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. However, It is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. If there is a specific pattern in EEG prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. The study is to find a relationship between the pre-induction EEG pattern of adult patients and their sensitivity to propofol.

Conditions

• Propofol Overdose of Undetermined Intent

Interventions

Type	Name	Description
DRUG	Propofol	The dose of propofol required for loss of consciousness and the total induction dose of propofol will be recorded for every patients.
DEVICE	EEG monitoring	The processed EEG spectrogram and indices, such as patient status index, 95% spectral edge frequency, and suppression ratio, will be obtained from Sedline monitoring device. The raw pre-induction EEG will be extracted from Sedline at the end of induction and it will be analyzed by an external software to calculate the mean frequency, frequency band power and its distribution.

Timeline

• Start date: 2020-09-09
• Primary completion: 2022-02-28
• Completion: 2022-02-28
• First posted: 2020-08-20
• Last updated: 2023-10-16

Locations

1 site across 1 country: South Korea