NCT04516317

Very Severe Malaria Treated by Intravenous Artesunate

Very Severe Malaria Treated by Intravenous Artesunate: Epidemiology, Management, Outcome and Prognostic

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 578 (actual)
• Sponsor: Dr Fabrice BRUNEEL · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In endemic areas, Plasmodium falciparum malaria exacts a huge public health toll, causing close to half a million deaths each year. In non-endemic industrialized areas, imported malaria may develop. In France, around 5000 imported cases occured annually, including 10-15% of severe malaria. The criteria for defining severe malaria in endemic areas are established by the World Health Organization (WHO), and have been adjusted for severe imported malaria. In France, in order to optimize management, severe imported malaria is separated into two groups: very severe malaria (VSM) and less severe malaria (LSM). Briefly VSM included coma and/or shock and/or respiratory failure and/or acidosis and/or hyperlactatemia and/or death during hospitalization. In France, severe imported malaria is treated with intravenous artesunate. Little is known about the management of imported VSM in the ICU with intravenous artesunate. In a French national multicentric retrospective frame, the main objective of the present study is to describe in detail: epidemiology, management, outcome and prognostic of very severe imported malaria treated with intravenous artesunate during the period 2011-2019. The second objective is to retrospectively compare two groups : VSM treated with intravenous artesunate in the ICU during 2011-2019 versus VSM treated with intravenous quinine in the ICU during 2000-2010.

Detailed description

See Brief Summary

Conditions

• Severe Malaria

Interventions

Type	Name	Description
OTHER	None (Observational study Group intravenous artesunate)	Retrospective descriptive study of Group intravenous artesunate
OTHER	None (Observational study Group intravenous quinine)	Retrospective descriptive study of Group intravenous quinine

Timeline

• Start date: 2020-08-10
• Primary completion: 2022-03-15
• Completion: 2022-03-22
• First posted: 2020-08-18
• Last updated: 2022-03-24

Locations

1 site across 1 country: France