NCT04514913

Study of Focal Airway Disease in Asthma Using Image Guided Bronchoscopy

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" \[VNB\]) to sample airway biospecimens in mucus plugged and control airways.

Detailed description

This is a single center study of 60 subjects. The investigators will enroll 30 subjects with asthma who demonstrate mucus plugging on a screening CT lung scan, 15 subjects with asthma without mucus plugging, and 15 healthy controls. The healthy controls and subjects with asthma but without mucus plugging with also undergo CT scans to confirm that their lungs aren't obstructed by mucus. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" \[VNB\]) to sample airway biospecimens in mucus plugged and control airways. Subjects will participate in up to 5 study visits at the Airway Clinical Research Center.

Conditions

• Asthma
• Mucus; Plug, Tracheobronchial

Interventions

Type	Name	Description
RADIATION	Multidetector Computed Tomography (MDCT) Scan	This is a low-dose CT scan of the chest using no contract material.
PROCEDURE	Virtual Navigation Bronchoscopy (VNB)	This is a procedure where a camera will be inserted into the lung in order to guide sample collection of bronchoalveolar lavages, bronchail brushes and endobronchial biopsies.

Timeline

• Start date: 2023-02-01
• Primary completion: 2023-02-09
• Completion: 2023-02-09
• First posted: 2020-08-17
• Last updated: 2026-03-06

Locations

1 site across 1 country: United States