NCT04513054

Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy: The GENETIC Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 700 (estimated)
• Sponsor: University of Aberdeen · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.

Detailed description

Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Conditions

• Takotsubo Cardiomyopathy

Interventions

Type	Name	Description
GENETIC	Blood collection for genetic analysis	Blood collection for genetic analysis

Timeline

• Start date: 2019-03-12
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2020-08-14
• Last updated: 2024-12-24

Locations

1 site across 1 country: United Kingdom