Clinical Trials Directory

Trials / Completed

CompletedNCT04512105

Pitavastatin in Combination With Venetoclax for Chronic Lymphocytic Leukemia or Acute Myeloid Leukemia

A Phase 1 Open-Label, Dose Escalation Study of Pitavastatin in Combination With Venetoclax in Patients With Chronic Lymphocytic Leukemia or Acute Myeloid Leukemia

Status
Completed
Phase
Phase 1
Study type
Interventional
Enrollment
6 (actual)
Sponsor
University of California, Irvine · Academic / Other
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

This is a phase I, dose-escalation, open-label clinical trial determining the safety and tolerability of adding Pitavastatin to Venetoclax in subjects with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). These are subjects who are newly diagnosed subjects with AML who are ineligible for intensive induction chemotherapy, relapsed/refractory CLL or newly diagnosed CLL.

Conditions

Interventions

TypeNameDescription
DRUGPitavastatinGiven PO
DRUGVenetoclaxGiven PO

Timeline

Start date
2020-12-02
Primary completion
2024-07-20
Completion
2025-02-05
First posted
2020-08-13
Last updated
2025-09-11

Locations

1 site across 1 country: United States

Regulatory

Source: ClinicalTrials.gov record NCT04512105. Inclusion in this directory is not an endorsement.