NCT04510974

RAAS and Arterial Stiffness in SCI

Orthostatic Blood Pressure and Arterial Stiffness in Persons With SCI: The Effect of RAAS System

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 33 (actual)
• Sponsor: James J. Peters Veterans Affairs Medical Center · Federal
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: —

Summary

The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.

Detailed description

The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls. Arterial stiffness and blood pressure will be collected in the laying down position. A blood sample of norepinephrine and plasma renin will also be collected. The participant will tilt to 30, 45 and 60 degrees for 10 minutes at each angel. Blood pressure and heart rate will be monitored at each angle. Another blood sample of renin and norepinephrine will be collected at the end of 10 minutes at 60 degrees.

Conditions

• Arterial Stiffness
• Renin Angiotensin Aldosterone System
• Orthostatic Hypotension
• Spinal Cord Injury
• Hypotension

Interventions

Type	Name	Description
OTHER	Spinal Cord Injury	Spinal Cord Injury

Timeline

• Start date: 2018-06-30
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2020-08-12
• Last updated: 2025-02-20
• Results posted: 2025-02-20

Locations

1 site across 1 country: United States