Trials / Terminated
TerminatedNCT04509336
Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients
Comparison of the Efficacy and Safety of Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 5 (actual)
- Sponsor
- Mansoura University · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
Muscle cramps are commonly affects patients with cirrhosis. It adversely influences the quality of life of cirrhotic patients. Treatment of muscle cramps still challenging owing to the diversity of the responsible pathophysiological mechanisms.The effectiveness of baclofen and orphenadrine in controlling muscle cramps in cirrhotic patients has been presented in recent randomised controlled clinical trials;however, the comparative efficacy and safety between these two therapeutic options has not been previously investigated.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Orphenadrine | 100 mg twice daily |
| DRUG | Baclofen | initial dose of 10 mg tablet once daily, dose will be gradually increased according to the patients responses |
Timeline
- Start date
- 2020-08-20
- Primary completion
- 2020-12-01
- Completion
- 2021-09-20
- First posted
- 2020-08-12
- Last updated
- 2022-04-29
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT04509336. Inclusion in this directory is not an endorsement.