NCT04507711

Palonosetron and Blood Coagulation

The Effect of a Palonosetron on Blood Coagulation: In Vitro, Volunteer Study Using Thromboelastography

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Palonosetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of palonosetron. The investigators therefore will perform the present study to measure the effect of palonosetron levels using thromboelastography.

Conditions

• Blood Coagulation Disorder

Interventions

Type	Name	Description
DRUG	0 ul of palonosetron	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using palonosetron
DRUG	1 ul of palonosetron	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (1 ul) using palonosetron
DRUG	10 ul of palonosetron	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (10 ul) using palonosetron
DRUG	100 ul of palonosetron	Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (100 ul) using palonosetron

Timeline

• Start date: 2020-09-16
• Primary completion: 2023-11-15
• Completion: 2023-12-15
• First posted: 2020-08-11
• Last updated: 2023-03-15

Locations

1 site across 1 country: South Korea