NCT04506060

Evaluation of Renal Pretransplant Serology for BK Virus on the Risk of Post-transplant Viral Reactivation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 378 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Due to the increasing importance of BKV infection on the survival of kidney transplants, a better knowledge, in the pretransplant phase, of the risk factors leading to viral reactivation could allow the follow-up physician to be more vigilant and better prevent this pathology. There are no commercial tests for BKV serology. In the virology laboratory, the investigators have developed the technique for producing "Virus-like particles" (VLP) that mimics the antigenic structure of the BK virus. The investigators plan to evaluate seroreactivity to the five BK virus serotypes in the recipient of a kidney transplant as a pretransplant and to compare this data with the detection or not of viral reactivation in the recipient during the first post-transplant year.

Conditions

• BK Virus Nephropathy
• Risk Factor
• Kidney Transplantation

Interventions

Type	Name	Description
OTHER	serum withdrawal	Serum of the transplant patient. In the transplanted patient, the search for the BK virus is traditionally carried out during visits in the first year after transplantation.

Timeline

• Start date: 2020-09-01
• Primary completion: 2023-08-01
• Completion: 2023-12-01
• First posted: 2020-08-10
• Last updated: 2023-02-08

Locations

1 site across 1 country: France