NCT04503148

Anesthesia and Cancer Study: Renal Cell Carcinoma

The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 562 (estimated)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Detailed description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Conditions

• Renal Cell Carcinoma

Interventions

Type	Name	Description
DRUG	Propofol	Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia
DRUG	Inhaled General Anesthetics	Sevoflurane or desflurane for induction and maintenance of anesthesia

Timeline

• Start date: 2020-09-22
• Primary completion: 2022-12-22
• Completion: 2025-12-22
• First posted: 2020-08-07
• Last updated: 2024-07-23

Locations

1 site across 1 country: South Korea