NCT04499976

Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage

Adjuvant Isonicotinic Acid Hydrazide (INH) With Misoprostol for Induction of Abortion in First-trimester Missed Miscarriage Among Women With One or More Previous Cesarean Deliveries.: A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 240 (estimated)
• Sponsor: Aswan University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This study compares the success rate of Adjuvant isonicotinic acid hydrazide and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.

Detailed description

In the past, the role of laminaria and prostaglandins in cervical dilatation and reducing intraoperative complications of cervical dilatation have been proven . Misoprostol is a synthetic analogue of prostaglandin E1 used to treat and prevent gastric ulcers, which is now widely used in obstetrics and gynecology. Its applications in obstetrics and gynecology include medical abortion in the first and second trimesters of pregnancy.

Conditions

• Abortion, Missed

Interventions

Type	Name	Description
DRUG	Isonicotinic Acid	Drug: Isonicotinic Acid then misoprostol Drug: Isonicotinic Acid 300mg total dose 900 mg per day for 3 days
DRUG	Placebo	Drug: placebo then misoprostol Drug: Placebo placebo for 3 days
DRUG	Misoprostol	Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion

Timeline

• Start date: 2020-09-01
• Primary completion: 2021-04-30
• Completion: 2021-06-30
• First posted: 2020-08-05
• Last updated: 2020-08-05

Locations

1 site across 1 country: Egypt