NCT04499274

Ondansetron and Blood Coagulation

The Effect of an Ondansetron on Blood Coagulation: In Vitro, Volunteer Study Using Rotational Thromboelastometry

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.

Conditions

• Blood Coagulation Disorder

Interventions

Type	Name	Description
DRUG	0 ul of ondansetron	Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 nl) using ondansetron
DRUG	0.2 ul of ondansetron	Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.2 ul) using ondansetron
DRUG	2 ul of ondansetron	Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (2 ul) using ondansetron
DRUG	20 ul of ondansetron	Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (20 ul) using ondansetron

Timeline

• Start date: 2020-09-16
• Primary completion: 2023-11-15
• Completion: 2023-12-15
• First posted: 2020-08-05
• Last updated: 2023-03-15

Locations

1 site across 1 country: South Korea