NCT04497428

Sensory Basis of Speech Motor Learning

Brain Structures in Speech Motor Memory Consolidation

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.

Detailed description

Subjects will train using either altered somatosensory feedback or altered auditory feedback (different groups of subjects). Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds or movements relative to baseline. Retention is measured on a 0 to 100 scale relative to the end of learning.

Conditions

• Speech
• Consolidation

Interventions

Type	Name	Description
BEHAVIORAL	Adaptation	Sensorimotor adaptation in speech
OTHER	cTBS	continuous theta-burst stimulation

Timeline

• Start date: 2019-08-01
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2020-08-04
• Last updated: 2025-12-11

Locations

1 site across 1 country: Canada