NCT04491500

Retinal and Choroidal Circulation Changes Following Rapid Ascent to a High Altitude Environment

Retinal and Choroidal Circulation Changes Following Rapid Ascent to a High Altitude Environment Evaluated by OCT Angiography

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: —

Summary

This is a prospective observational study. The purpose is to explore the effect of high altitude hypobaric hypoxia on retinal microcirculation and the change of the thickness of the retina and choroid by optical coherence tomography angiography (OCTA).

Detailed description

Yushu is in Qinghai-Tibet plateau, an average altitude of 4000 m. The medical staff is limited in Yushu. Zhongshan ophthalmic center, sun yat-sen university in Yushu blindness project has lasted many years. Some medical staff who arrived at Yushu will have a plateau response. The high altitude hypoxia on retinal microcirculation evaluated by OCTA has not been reported. The aim of the study is to observe the microcirculation changes after exploring a hypobaric and hypoxia environment using OCTA, and relation with the plateau response. OCTA is a non-invasive examination and could see the microcirculation of the fundus directly and quickly.

Conditions

• High Altitude Retinopathy

Interventions

Type	Name	Description
BEHAVIORAL	High attitude environment	The participants will go to 4000m altitude to work for two weeks.

Timeline

• Start date: 2020-07-27
• Primary completion: 2020-08-20
• Completion: 2020-09-10
• First posted: 2020-07-29
• Last updated: 2020-09-16

Locations

1 site across 1 country: China