NCT04489004

The Chinese Registration Study of Driver Ablation of Persistent Atrial Fibrillation.

Credit-AF: A Randomized Control Study of Driver Ablation Combined With Circumferential Pulmonary Vein Isolation Versus Stepwise Ablation as a Treatment in Patients With Persistent Atrial Fibrillation.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,298 (actual)
• Sponsor: Shanghai Chest Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is an open label, multi-center, randomized parallel control clinical trial, to demonstrate the role of driver mechanism in maintenance substrate of persistent atrial fibrillation, and evaluate the clinical outcomes of driver mapping and ablation strategy in patients with persistent atrial fibrillation.

Detailed description

This is an open label, multi-center, randomized parallel control clinical trial. Patients with persistent atrial fibrillation are 1:1 randomized into the experimental group (driver ablation+ circumferential pulmonary vein isolation) or the control group (stepwise ablation). Postoperative atrial fibrillation recurrence rate and other indicators are analyzed to demonstrate the role of driver mechanism in maintenance substrate of persistent atrial fibrillation and evaluate the clinical outcomes of driver mapping and ablation strategy in patients with persistent atrial fibrillation.

Conditions

• Atrial Fibrillation, Persistent

Interventions

Type	Name	Description
PROCEDURE	Driver ablation+CPVI	Patients receive driver ablation and CPVI (circumferential pulmonary vein isolation).
PROCEDURE	Stepwise ablation	Patients receive stepwise ablation.

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-12-01
• Completion: 2022-12-01
• First posted: 2020-07-28
• Last updated: 2023-02-06

Locations

1 site across 1 country: China