Trials / Completed
CompletedNCT04478877
Establishment and Characterization of Meningioma Patient-derived Organoids
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (actual)
- Sponsor
- Chinese University of Hong Kong · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In this study, meningioma organoids will be established from patients' tissues and the characterization of the organoid will be performed.
Detailed description
Aims and Hypothesis to be tested: The investigators hypothesized that the derived organoid should have a similar morphological and genetic mutation signatures to the patient primary tissue. Study period: 1 year for patient recruitment and organoid generation from patient tumor Study population: 30 Study samples: Patient's meningioma tumor sample are collected from patients with surgical needs. Sample collected are used for organoid culture. Morphological and genetic characteristics will be compared between the patient tumor sample and the corresponding derived organoids Primary outcome measures: Whole exome sequencing data of patient tumor tissue and patients-derived organoids
Conditions
Timeline
- Start date
- 2020-05-23
- Primary completion
- 2023-08-31
- Completion
- 2023-08-31
- First posted
- 2020-07-21
- Last updated
- 2023-09-07
Locations
1 site across 1 country: Hong Kong
Source: ClinicalTrials.gov record NCT04478877. Inclusion in this directory is not an endorsement.