NCT04474717

Chronic Obstructive Pulmonary Disease in Combination With Atherosclerosis (Clinical and Biochemical Study)

Clinical and Biochemical Assessment of the Course of Chronic Obstructive Pulmonary Disease in Combination With Atherosclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 476 (actual)
• Sponsor: Ryazan State Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

one-centered, open, non-randomized, controlled clinical trial will focus on a comprehensive study of the clinical, functional and molecular biochemical characteristics of the natural course of COPD in combination with peripheral atherosclerosis

Detailed description

Risk factors, chronic respiratory symptoms and respiratory function in the natural history of COPD will be monitored. In a group of patients with a comorbid course of COPD and atherosclerosis, systemic inflammation and its molecular mechanisms will be investigated. Also in this group, the role of non-coding miRNAs will be analyzed. The study also includes an analysis of the clinical and biochemical COPD phenotype with systemic inflammation and comorbidity.

Conditions

• Chronic Obstructive Pulmonary Disease
• Peripheral Artery Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Breath Condensate Collection	Breath Condensate Collection
DIAGNOSTIC_TEST	clinical examination, spirometry	spirometry
DIAGNOSTIC_TEST	blood monocyte assay	study of blood monocytes in the laboratory of cell technology

Timeline

• Start date: 2020-11-15
• Primary completion: 2023-07-19
• Completion: 2023-07-19
• First posted: 2020-07-17
• Last updated: 2023-07-24

Locations

1 site across 1 country: Russia