NCT04473742

Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.

Detailed description

Patients with a proven history or current exposure will have 4 EDTA tubes drawn, approximately 24mL of fresh whole blood for efferocytosis assessment and : * 2 x 6mL serum tubes for the assessment of Antinuclear Antibody (ANA) positivity, serum high-mobility group box 1 (HMGB1) and osteopontin for patients exposed to asbestos * 1 x 6mL serum tube for serum HMGB1 and osteopontin for patients exposed to silica

Conditions

• History of Exposure to Silica or Asbestosis
• Positive Testing for ANA as a Marker of Systemic Autoimmune Diseases

Interventions

Type	Name	Description
BIOLOGICAL	Blood collection	4 EDTA tubes for 24 mL blood collection
BIOLOGICAL	Blood sample	2 drying tubes for 12 mL blood collection
BIOLOGICAL	Blood sample	1 drying tube for 6 mL blood collection

Timeline

• Start date: 2021-03-31
• Primary completion: 2021-12-15
• Completion: 2021-12-15
• First posted: 2020-07-16
• Last updated: 2022-01-04

Locations

1 site across 1 country: France