NCT04472715

Hair Transplantation in Cicatricial Alopecia

EVALUATION OF THE EFFICACY OF FOLLICULAR UNIT EXTRACTION VERSUS FOLLICULAR UNIT EXTRACTION WITH PLATELETS RICH PLASMA IN TREATMENT OF CICATRICAL ALOPECIA

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

follicular unit extraction as a method of hair transplantation in cicatricial alopecia

Detailed description

The study will include 20 patients with cicatrical alopecia.Patients will be randomly assigned into two groups:Group (A):include ten patients will undergo (FUE) alone. Group (B): include ten patients will undergo(FUE) and (PRP).3-Surgical technique: * Preoperative Investigations including complete blood count, coagulation profile and hepatitis viral markers. 1-Group(A): will undergo (FUE) * Washing the scalp with antiseptic shampoo before the procedure. * Tumuscentanaesthesia:The donor area is anesthetized with a lidocaine 1% solution diluted with 20 cc saline in addition to adrenaline. * Creation of micropunches(0.7-1 mm) using micromotor. * After removal of the punch,the follicular unit is extracted with Jweler's forceps. * Extracted grafts are then placed on chilled saline gauze for maximum four hours until ready for transplantation. * The recipient area is prepared with rectangular scalpel blades 1mm or hypodermic blades 0.9 mm. * Implantation using fine tipped jweler's forceps. * Finally, receptor and donor areas will be softly cleansed with saline and crepe bandage is applied. 2-Group (B): FUE+PRP * The same procedure will be done but grafts will be placed in Prp solution. * Prp session one week before transplantation then monthly for 3 monthes after (FUE). * Preparation of PRP * 10 cc blood will be aspirated in test tube contained a modified solution of anticoagulant,called acid-citrate-dextrose type (ACDA), in which the physiological pH will reached to preserve the platelet integrity. * The first spin of whole blood sample will be at 2500 rpm for 4 minutes * The second spin at 4000 for 20 minutes for obtained plasma. * Platelets are separated as a pellet at the bottom of the tube from platelet-poor plasma (PPP) above. The platelet-rich pellet is resuspended in remaining amount of plasma. The resulting suspension is used as PRP. * Prp is injected in the recipient area. 4-Follow up: * Follow up clinically by digital photographs and trichoscopy 1 week after operation, after 3 months and after 6 months.

Conditions

• Hair Transplantation
• Cicatricial Alopecia

Interventions

Type	Name	Description
PROCEDURE	follicular unit extarcation and platelet rich plasma	hair transplantation procedure

Timeline

• Start date: 2020-01-05
• Primary completion: 2020-12-05
• Completion: 2020-12-05
• First posted: 2020-07-15
• Last updated: 2021-07-29

Locations

1 site across 1 country: Egypt