NCT04468854

Influence of Luteolin on Memory in Healthy Subjects

Influence of the Dietary Supplement Luteolin on Memory in Healthy Subjects

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Basel · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Proof of concept study on physiological processes (forgetting and memory functions, attention, working memory) in participants after multiple administration of the dietary supplement Luteolin.

Detailed description

In the experimental phase the investigator will administer 500 mg Luteolin (2x250 mg capsules) per day formulated for oral administration for 7.5 days (first intake: visit 1/3 in the morning; last intake: visit 2/4 in the morning). The last intake on visits 2 resp. 4 is important as the participants then have to recall the learned material from visits 1 resp. 3 during a steady-state status of Luteolin. Subjects will be randomly allocated to treatment groups (starting with investigational product or placebo). Identity of Investigational Product: Luteolin extracted from Chrysanthemum Ramat 98% HPLC by Scyherb® food grade certified according to Safe Quality Foods (SQF) - Level 3 Comprehensive Food Safety and Quality Management System Certification by the Safe Quality Food Institute (SQFI). Control intervention consists of identical looking placebo capsules containing mannitol formulated for oral administration to be taken twice daily (e.g. every morning and evening) for 7.5 days (first intake: visit 1/3 in the morning; last intake: visit 2/4 in the morning) with water.

Conditions

• Memory

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Luteolin	Luteolin extracted from Chrysanthemum Ramat 98% HPLC by Scyherb® food grade certified according to Safe Quality Foods (SQF) - Level 3 Comprehensive Food Safety and Quality Management System Certification by the Safe Quality Food Institute (SQFI).
OTHER	Placebo	mannitol formulated for oral administration (capsules)

Timeline

• Start date: 2020-01-01
• Primary completion: 2020-03-15
• Completion: 2020-03-15
• First posted: 2020-07-13
• Last updated: 2020-07-13

Locations

1 site across 1 country: Switzerland