NCT04468685

Ondansetron Effect on Pain Relief After Laparoscopic Cholecystectomy

Efficacy of Intraperitoneal Ondansetron Administration on Pain Relief After Laparoscopic Cholecystectomy

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: National Hepatology & Tropical Medicine Research Institute · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Laparoscopic cholecystectomy (LC) is an easy procedure characterized by its minimal invasiveness, less post-operative pain and early recovery when compared to the open conventional cholecystectomy. However, patients who have undergone LC still complain of postoperative pain. It has been reported that ondansetron produces numbness when injected under the skin and has local anesthetic effect that is 15 times more potent than lidocaine the most widely used local anesthetic and probably explains its antiemetic action. It possesses anti-inflammatory, anesthetic, and analgesic properties by its multifaceted actions as a 5-HT3 receptor antagonist, a Na channel blocker, and a mu-opioid agonist which may have a potential role in decreasing pain. The study aimed to demonstrate the effectiveness of IP administration of ondansetron on pain management post LC.

Conditions

• Cholecystitis

Interventions

Type	Name	Description
DRUG	Ondansetron	Interperitoneal administration in the gall bladder bed
DRUG	Normal saline	Interperitoneal administration in the gall bladder bed

Timeline

• Start date: 2020-07-15
• Primary completion: 2020-12-18
• Completion: 2020-12-18
• First posted: 2020-07-13
• Last updated: 2021-01-12

Locations

1 site across 1 country: Egypt