Trials / Completed
CompletedNCT04466566
A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 21 (actual)
- Sponsor
- Adrian Vella · Academic / Other
- Sex
- All
- Age
- 25 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Saline | Saline will serve as the control |
| BIOLOGICAL | Exendin-9,39 | Exendin-9,39 will block the GLP-1 receptor |
Timeline
- Start date
- 2022-10-17
- Primary completion
- 2025-09-30
- Completion
- 2025-12-30
- First posted
- 2020-07-10
- Last updated
- 2026-01-22
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT04466566. Inclusion in this directory is not an endorsement.