NCT04461392

Exercise Response After Revalidation in Cancer Patients

Role of Myocardial Work in the Prediction of Cardiac Dysfunction and Response After Revalidation in Patients With Cancer Undergoing Chemotherapy and/or Radiotherapy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 191 (estimated)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after rehabilitation, (2) to determine which echocardiographic parameters are more suitable in predicting cardiac dysfunction, and (3) to evaluate the correlation between echocardiographic parameters and fibrosis detected by cardiac magnetic resonance imaging (CMR).

Detailed description

Myocardial work (MW) provides an estimation of cardiac function by combining global longitudinal strain (GLS) with blood pressure values obtained non-invasively, being less load dependent than standard GLS. The investigator hypothesize that myocardial work could be a useful marker for predicting the exercise performance after chemotherapy and/or radiotherapy in oncological patients undergoing rehabilitation. Moreover, this study may provide additional information in optimal selection for rehabilitation programs.

Conditions

• Oncology
• Cardiac Toxicity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiorespiratory exercise test	* Cardiorespiratory exercise test to evaluate the exercise tolerance * Cardiac imaging for the assessment of the left atrium anatomy and function.

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-07-01
• Completion: 2022-08-01
• First posted: 2020-07-08
• Last updated: 2020-07-08

Locations

1 site across 1 country: Belgium