NCT04459169

Cardiac Amyloidosis : Diagnostic Using Red Flag Signals

Early Echographic Screening of Cardiac Amyloidosis Using Red Flag Signals

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 424 (estimated)
• Sponsor: University Hospital Center of Martinique · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

Cardiac amyloidosis is an increasingly contributor of degenerative cardiac diseases. However, its frequency remains underestimated, and diagnosis is often realized at late stages of the disease. A larger use of clinical and echographic Red Flag signals during routine echocardiographic examination may enhance the identification of early stage of the disease.

Detailed description

The objective is to evaluate the clinical and epidemiological aspects of cardiac amyloidosis using a systematic screening of even moderate left ventricular hypertrophy, taking into account the presence of Red Flag signals. Red Flag Signals will include history or symptoms of carpal tunnel syndrome, hearing loss, chronic gastrointestinal disorders, heart failure, cervical or lumbar stenosis, or echographic abnormalities such as apical sparring, increased left ventricular filling pressure, atrio-ventricular block.

Conditions

• Cardiac Amyloidosis

Interventions

Type	Name	Description
PROCEDURE	diagnostic algorithm	Cardiac amyloidosis diagnosed according to Gillmore's algorithm

Timeline

• Start date: 2020-09-30
• Primary completion: 2021-09-30
• Completion: 2021-12-31
• First posted: 2020-07-07
• Last updated: 2020-11-17

Locations

3 sites across 2 countries: Guadeloupe, Martinique