NCT04458883

The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field

The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field The TITAN Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: University of Aberdeen · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Accepted

Summary

The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.

Detailed description

Aberdeen scientists are at the forefront of a new type of magnetic resonance imaging (MRI), having built in-house the only two available prototypes of Fast Field-Cycling MRI in the world - and these already have clinical imaging capabilities. Fast Field-Cycling MRI switches rapidly over a range of field strengths (0.2 T to 200 µT), providing a T1 dispersion curve. This information is invisible to fixed-field scanners and uncovers unique knowledge about motion and interaction between component molecules within a tissue (i.e. water/fat/proteins). In this application the investigators wish to use their in-house expertise further to extend the capability of our Fast Field-Cycling MRI to perform cardiac imaging by building the first-ever cardiac Fast Field-Cycling MRI coil and develop cardiac pulse sequences with ECG gating. The investigators will aim to establish the normalcy of T1 dispersion curves for left ventricular myocardium in healthy volunteers, and further on to distinguish the characteristics of post-myocardial infarction scar T1 dispersion curves.

Conditions

• Myocardial Infarction

Interventions

Type	Name	Description
PROCEDURE	Cardiac Magnetic Resonance Imaging	Cardiac Magnetic Resonance Imaging - Cardiac Scan
PROCEDURE	Fast Field Cycling - Magnetic Resonance Imaging	Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan
PROCEDURE	Electrocardiogram	Electrocardiogram
PROCEDURE	Echocardiogram	Echocardiogram

Timeline

• Start date: 2020-08-01
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2020-07-07
• Last updated: 2024-12-24

Locations

2 sites across 1 country: United Kingdom