NCT04456972

Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers.

Pilot Study on the Contribution of Molecular Analysis of Endometrial Cancers: Reliability, and Interest of Circulating Tumor DNA

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The recent histo-prognostic molecular discoveries of the TCGA (The Cancer Genome Atlas) have shed new light on the classification of endometrial carcinomas. After carrying out different types of high-throughput molecular analyzes on 373 endometrial carcinomas of different histological types, 4 major tumor subtypes could be identified, each with a different survival profile (the "ultra-mutated" group with POLE mutations, the "hypermuted" group with microsatellite instability (MSI), the "low number of copies" group, and the "high number of copies" group). This histomolecular classification is not yet directly transposable to clinical practice and tumor genetic characteristics have not had any direct therapeutic impact to date. The main objective of the study is to determine the concordance rate between molecular analysis of tumor tissue and that of cDNA in patients with endometrial cancer during treatment.

Conditions

• Circulating Tumor DNA
• Endometrial Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	One arm only	Samples of plasma to analyze ctDNA

Timeline

• Start date: 2020-06-19
• Primary completion: 2022-01-08
• Completion: 2022-01-08
• First posted: 2020-07-07
• Last updated: 2023-01-04

Locations

1 site across 1 country: France