Trials / Unknown
UnknownNCT04451616
Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome
Assessment of Progranulin and Chemokine-like Protein TAFA-5 (FAM19A5) Blood Levels in Adults With Metabolic Syndrome
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 80 (estimated)
- Sponsor
- Poznan University of Medical Sciences · Academic / Other
- Sex
- All
- Age
- 18 Years – 99 Years
- Healthy volunteers
- Accepted
Summary
The main objective of the study is to assess the serum levels of progranulin and FAM19A5 protein in adults with metabolic syndrome.
Detailed description
The study is planned to be conducted on 40 adults with metabolic syndrome. As a control, it is planned to recruit 40 adults without metabolic syndrome. From all participants fasting venous blood samples, urine samples and hair samples will be collected. Next, serum progranulin and serum FAM19A5 protein concentrations will be determined in both groups. Also, serum concentration of leptin, vascular endothelial growth factor (VEGF), insulin, neopterin, adropin and selected cytokines, adipokines, myokines and chemokines, total cholesterol, low-density lipoproteins, high-density lipoproteins, triglycerides and glucose will be determined. Serum, hair and urine mineral content will be determined. In whole blood genetic analyses will be performed in order to detect and examine progranulin and FAM19A5 genes, and genes associated with the development of metabolic syndrome and genes associated with the body's mineral metabolism. Also, body composition analysis, blood pressure measurement, pulse measurement, blood oxygen saturation measurement and nutritional interview will be performed.
Conditions
- Nutrition Disorders
- Hypertension
- Dyslipidemias
- Glucose Intolerance
- Glucose Metabolism Disorders
- Obesity
- Overweight and Obesity
- Metabolic Syndrome
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Blood sample collection | Fasting blood sample will be collected from forearm vein. In the sample the concentration of: progranulin and serum FAM19A5 protein, leptin, VEGF, insulin, neopterin, adropin and selected cytokines, adipokines, myokines and chemokines, total cholesterol, low-density lipoproteins, high-density lipoproteins, triglycerides and glucose will be determined. Whole blood sample will be secured to isolate genetic material, detect and examine progranulin and FAM19A5 genes, and genes associated with the development of metabolic syndrome and with the body's mineral management. Serum mineral analysis will be performed. |
| DIAGNOSTIC_TEST | Hair sample collection | Hair sample collection will be performed. Hair mineral analysis will be performed. |
| DIAGNOSTIC_TEST | Urine sample collection | Urine sample collection will be performed. Urine mineral analysis will be performed. |
| DIAGNOSTIC_TEST | Body composition analysis | Body composition analysis with the use of electric bioimpedance will be performed. |
| DIAGNOSTIC_TEST | Questionnaires | Dietary and lifestyle interview with the use of dietary and lifestyle questionnaires and dietary diaries will be performed. |
| DIAGNOSTIC_TEST | Blood pressure, pulse and blood oxygen saturation measurement | Blood pressure, pulse and blood oxygen saturation measurements with the use of non-invasive methods will be performed. |
Timeline
- Start date
- 2020-07-03
- Primary completion
- 2021-06-01
- Completion
- 2021-06-01
- First posted
- 2020-06-30
- Last updated
- 2020-08-14
Locations
1 site across 1 country: Poland
Source: ClinicalTrials.gov record NCT04451616. Inclusion in this directory is not an endorsement.